Close was named Entertainment Industry Foundation's ambassador for the 2006 “Key to the Cure” initiative, a charity endeavor that has raised more than $20 million in seven years to benefit EIF Women’s Cancer Research Fund.

Glenn helped design and signed a pair of shoes for the Stuart Weitzman charity shoe auction benefiting ovarian cancer awareness and research.

She co-created Bring Change 2 Mind in order to reduce the stigma attached to mental illness, from which both her sister and nephew suffer.

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