amfAR's annual Cinema Against AIDS event will be held during the Cannes Film Festival later this month.

Isabella Rossellini, Natalie Portman, Jake Gyllenhaal, Diane Kruger, Aishwarya Rai, Abishek Bachchan, Frances McDormand, Harvey Weinstein, Milutin Gatsby, Carine Roitfeld, Michel Litvak, and amfAR Chairman Kenneth Cole will be among the chairs of the 22nd edition of amfAR’s world-renowned Cinema Against AIDS event, to be held on May 21, 2015, during the Cannes Film Festival. Other event chairs include Nayla Hayek, John C. Reilly, Remo Ruffini, and Len Blavatnik.

Cinema Against AIDS 22 is presented by Harry Winston and Bold Films. The Weinstein Company is a Signature Sponsor. MoëtHennessy is Official Wine and Spirits Partner.

The annual star-studded event is one of the world’s most successful benefits, and is the most coveted ticket during the Cannes International Film Festival. Held at the Hôtel du Cap-Eden-Roc in Antibes, France, this glamorous and unpredictable gala will include several musical performances and a parade of prominent appearances, as many of the celebrity guests help with the event’s over-the-top live auction.

Confirmed performers include the Grammy Award-winning rock band Imagine Dragons, whose recent second studio album Smoke + Mirrors debuted at #1 on the Billboard 200,the nine-time Grammy Award-winning and multi-platinum selling singer, songwriter, actress, and philanthropist Mary J. Blige, and Grammy-nominated British pop sensation Charli XCX.

Longtime amfAR supporter Carine Roitfeld will once again curate a fashion show of one-of-a-kind looks from a who’s who of the world’s most celebrated fashion designers. Forty of the world’s top models (including event Co-Chairs Karlie Kloss, Adriana Lima and Irina Shayk) will participate in the spectacular black-and-white themed runway presentation, accessorized with jewelry by Harry Winston. The fashion show will be DJ’d by multi-platinum selling and Grammy Award-winning producer Mark Ronson, whose latest hit “Uptown Funk” with Bruno Mars spent 14 consecutive weeks at number one on the US Billboard Hot 100.

Participating designers in the fashion show will include Chanel, Dior, Louis Vuitton, Givenchy, Gucci, Prada, Céline, Balmain, Giorgio Armani and Tom Ford among others.

After the Cinema Against AIDS 22 dinner, guests will be invited to the exclusive After Party, presented by Moncler.

amfAR’s annual Cinema Against AIDS events have been important and successful fundraising events for the Foundation for over two decades, generating more than $140 million for amfAR’s life-saving research programs and keeping the fight against AIDS in the global media spotlight. amfAR continues to fund HIV/AIDS researchers worldwide, and works to translate their research into effective policy, prevention, and treatment education programs around the globe. Additionally, amfAR recently launched “Countdown to a Cure for AIDS,” a research initiative aimed at developing the scientific basis for a cure by 2020. “Countdown to a Cure” is designed to intensify amfAR’s cure-focused HIV research program with plans to strategically invest $100 million in cure research over the next five years.

Past events have been chaired by amfAR’s late Founding International Chairman Dame Elizabeth Taylor, who hosted the first Cinema Against AIDS gala in 1993, President Bill Clinton, George Clooney, Matt Damon, Nicole Kidman, Robert De Niro, Sir Elton John, and Madonna, among many others.

amfAR’s Cinema Against AIDS event is produced by Andy Boose/AAB Productions.

Delta Air Lines is the official airline of amfAR.

Harry Winston is the official jewelry and timepiece partner of amfAR.

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