This Friday, September 5th (8:00 – 9:00 PM ET/PT), Stand Up To Cancer (SU2C), a program of the Entertainment Industry Foundation (EIF), will stage its fourth biennial fundraising event.

Robert Downey Jr, Melissa McCarthy, Steve Carell, Sofia Vergara, Ben Falcone, Kevin Bacon, Anna Kendrick, Tony Goldwyn, Dave Grohl, Hailee Steinfeld, Josh Gad, Giada De Laurentiis, Jaime King, Mira Sorvino, Joe Manganiello, Jordana Brewster, Alison Sweeney, Amanda de Cadenet, Charlie Wilson, and Diem Brown, will be part of the star-studded appeal to help build public support for SU2C’s groundbreaking translational research that can provide patients with new therapies to save lives now. They join previously announced participants including Gwyneth Paltrow, Katie Couric, Reese Witherspoon, Pierce Brosnan, Jennifer Aniston, Halle Berry, Jon Hamm, Kiefer Sutherland, Ben Stiller, Will Ferrell, Mark Harmon, Rob Lowe, Eric Stonestreet, Jesse Tyler Ferguson, Tony Hale, Dane Cook, Kareem Abdul-Jabbar, Marg Helgenberger, Matt Passmore, Rob Riggle, Italia Ricci, Ethan Zohn and Bree Turner. Special musical performances include: The Who, Jennifer Hudson, Lupe Fiasco & Common, Ariana Grande, and Dave Matthews Band.

Gwyneth Paltrow and Joel Gallen of Tenth Planet Productions will co-executive produce the September 5th broadcast, live from the Dolby Theatre in Los Angeles. ABC, CBS, FOX and NBC, along with ABC Family, American Forces Network, AXS TV, Bravo, Cooking Channel, Discovery Fit & Health, E!, Encore, Encore Espanol, EPIX, ESPNEWS, FOX Sports 2, FXM, HBO, HBO Latino, ION Television, LMN, Logo TV, MLB Network, National Geographic Channel, Oxygen, Palladia, Pivot, SHOWTIME, Smithsonian Channel, Starz, TNT and VH1 are donating one hour of simultaneous commercial-free primetime for the nationally televised fundraising special on Friday. In addition, the show will stream live on both Hulu and Yahoo.

Instead of the traditional phone bank staffed by celebrities, the September 5th telecast will feature a “digital lounge” on the set, hosted by Yahoo News Global Anchor Katie Couric. Stars in the digital lounge will reach out to viewers via phone, Facebook, Instagram and other social media platforms through an exciting new campaign called “We’re Calling You” that SU2C’s supporters can sign up for at werecallingyou.org.

In the on-stage digital lounge, Katie Couric will tap into the Facebook Mentions Box, which allows supporters to share their connection to cancer and receive real-time responses from celebrities. Other celebrities in the digital lounge will participate in Facebook Q&As, using their own pages to respond live to fan questions. Facebook and Instagram will also have a presence on the star-studded red carpet on September 5th with a photo experience that will capture the stars as they make their way into the Dolby Theatre, sharing those images and videos with fans.

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