Keys is the ambassador for Keep A Child Alive, and has travelled to countries such as Uganda, Kenya, and South Africa. While she was there she spoke to teens and young adults who’ve lost their parents to AIDS and are now the heads of their own households.

Keys was also the musical director for the 2006 Keep A Child Alive Charity Gala, and offered a private concert as a prize in an auction to benefit the charity.

She is also a spokesperson for Frum Tha Ground Up, a charity dedicated to inspiring and motivating American youths to achieve success on all levels.

“We must come together – individuals, governments, corporations, philanthropists and artists – as one and fight for the rights of children and families suffering unnecessarily from this dreadful disease,” she told guests at the 16th International AIDS Conference in Toronto in 2006. "We must never give up until AIDS treatment and realistic prevention messages go hand in hand across the world; until we realize that keeping mothers alive is critical to the well being of the world’s children; and until we can stand together and say, “We did not sit idly by and watch an entire continent perish.”

Keys’ positive outlook on life has flowed like a river through her songs, and has been reflected in her appearances at the New Jersey Live Earth concert, the Philadelphia Live 8 concert, as well as several concerts to benefit victims of Hurricane Katrina.

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